HS Fighters with Patented Metafolin and Bioactiv B12 More Absorbable Folate and B12 in 1 Capsule Than 6 Servings of Green Leafy Vegetables
Bottle Label
Certified "A" Rated
GMP Quality
> L-Methylfolate
> Methyl-B12
> Vitamin B6
High Absorption Formula

L-Methylfolate (Metafolin®)

Natural Folic Acid
The Form of Folate Your Body Prefers
Patented L-Methylfolate (800 mcg), Methyl-B12 (1000 mcg), B6 (30 mg)
USPS First Class (2-6 Days) with Package Tracking
Since 2002:  L-Methylfolate is the one and only source of folate in
HS Fighters™ with Bioactiv Folate™ ...
  • Bioactiv Folate™ is the biologically active form of folic acid
  • Bioactiv Folate™ is naturally occurring and the form of folate your body prefers
  • Bioactiv Folate™ bypasses obstacles to absorbing folic acid, does not accumulate in the blood like folic acid, and is the only form of folate that pass through the blood-brain barrier
  • Bioactiv Folate™ is so unique, the ingredient is protected under law by a U.S. Patent as Metafolin®
  • Bioactiv Folate™ has been safety tested as a dietary ingredient and registered with the FDA as Metafolin®

Are you converting Folic Acid to L-Methylfolate?

Folic acid is allowed to be labeled folate or folicin. However, none of these are the active form of folate known as L-Methylfolate (or L-5-MTHF) which your body can put to work. It takes four separate biochemical reactions for your body to turn folic acid into active folate:

Absorption and Transformation Steps of Folic Acid vs Bioactiv Folate

Medical studies have shown that the conversion of folic acid into L-Methylfolate is frequently disrupted by genetic factors, age-related problems, medications and metabolic obstacles.1,2

  • Up to 40% of adults are affected by genetic flaws that limit the amount of folic acid converted to the active folate (L-Methylfolate) that neutralizes homocysteine.3-10
  • Transformation of folic acid into active folate (L-Methylfolate) falls off after ingesting 200 mcg, and is saturated at doses in the region of 400 mcg. Higher doses result in unabsorbed folic acid circulating in the blood, and we do not know the long term biological effects of a lifetime of exposure to unmodified synthetic folate.1,10


Unlike most B vitamin formulas, HS Fighters™ with Bioactiv Folate™ provides the active forms of folate (as L-Methylfolate) and B12 (as Methylcobalamin) to bypass obstacles that may limit your body's ability to absorb and transform these vitamins into active nutrients.

Supplement Facts

Directions: Take one capsule daily, or as recommended by a healthcare professional. HS Fighters™ does NOT contain yeast, dairy, egg, gluten, soy, wheat, sugar, starch or artificial color, flavor or fragrance.

Quality Assurance

Labeling for HS Fighters™ with Bioactiv Folate™ accurately represent its identity, strength, composition, quality and purity.
HS Fighters is created with great care at our FDA-approved nutraceutical facility consistently "Rated A" by the Natural Products Association and independent third party inspectors. Every purchase is protected by our Total Satisfaction Money-Back Guarantee.

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1 Kelly P, McPartlin J, Goggins M, Weir DG, Soctt JM. Unmetabolozed folic acid in serum: acute studies in subjects consuming fortified food and supplements. Am J Clin Nutr. 1997;65:1790-5>

2 Morita H, Taguchi J, Kurihara H, Kitaoka M, Kaneda H, Kurihara Y, Maemura K, Shindo T, Minamino T, Ohno M, Yamaoki K, Ogasawara K, Aizawa T, Suzuki S, Yakazi Y. Genetic polymorphism of 5,10-methylenetetrahydrofolate reductase (MTHFR) as a risk factor of coronary artery disease. Circulation 95:2032-2036, 1997.

3 Goyette P, Christensen B, Rosenblatt DS, Rozen R. Severe and mild mutations in cis for the methylenetetrahydrofolate reductase (MTHFR0 gene, and description of 5 novel mutations in MTHFR. Am. J. Hum. Genet. 59:1268-1275, 1996.

4 Bailey LB,Gregory JF. Polymorphisms of methylenetetrahydrofolate reductase and other enzymes: metabolic significance, risks and impact on folate requirement. J Nutr 1999;129(5):919-22.

5 Deloughery TG, Evans A, Sadeghi A, et al. Common mutation in methylenetetrahydrofolate reductase. Correlation with homocysteine metabolism and late-onset vascular disease. Circulation 1996;94(12):3074-78.

6 Kim YI. Methylenetetrahydrofolate reductase polymorphisms, folate, and cancer risk: a paradigm of gene-nutrient interactions in carcinogenesis. Nutr Rev 2000;58:205-17.

7 Choi S-W, Mason JB. Folate and carcinogenesis: an integrated scheme. J Nutr 2000;130:129-32.

8 Ma J, Stampfer MJ, Hennekens CH, et al. Methylenetetrahydrofolate reductase polymorphism, plasma folate, homocysteine, and risk of myocardial infarction in US physicians. Circulation 1996;94(10):2410-16.

9 Miyao M, Morita H, Hosoi T, et al. Association of methylenetetrahydrofolate reductase(MTHFR) polymorphism with bone mineral density in postmenopausal Japanese women. Calcif Tissue Int 2000;66:190-94.

10 Lucock MD, Wild J, Smithells R, Hartley R. Invivo characterization of the absorption and biotransformation of pteroylglutamic acid in man: a model for future studies. Biochem Med Metaab Biol 1989;42:30-42.

HS Fighters with Bioactiv Folate

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These statements have not been evaluated by the Food And Drug Administration.
This product is not intended to diagnose, treat, cure, or prevent any disease.
Metafolin® is a registered trademark of Merck KGaA.